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Year : 2013  |  Volume : 23  |  Issue : 1  |  Page : 33-38

Chemotherapy-induced cardiotoxicity: Subclinical cardiac dysfunction evidence using speckle tracking echocardiography

Department of Medical and Pediatric Sciences, AOU Policlinic of University Catania, Italy

Correspondence Address:
Ines Monte
Clinical Echocardiography - A.O.U. Policlinic VE, Via Santa Sofia 78, 95125 Catania
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Source of Support: None, Conflict of Interest: This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors and there are no conflicts of interest for all authors.

DOI: 10.4103/2211-4122.117983

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Objectives: In our study, we aimed to identify early markers of cardiac dysfunction in patients treated with mitoxantrone. We also looked at cardiac functional changes during therapy by analyzing longitudinal deformation and by measuring left ventricular (LV) and left atrial (LA) global strain. Materials and Methods: LA and LV global longitudinal strain were analyzed in 20 patients affected by multiple sclerosis and treated with mitoxantrone. Patients underwent echocardiography before treatment, after every drug administration during the 12-months treatment period, and finally after 6 and 12 months of drug discontinuation. Results: Compared with baseline values, patients showed a significant reduction of both LA and LV longitudinal global strain at the end of treatment with mitoxantrone (LA_GS% T10 vs. T0 values: 15,2 ± 12,5 vs. 20,2 ± 11,1; LV_GS%: ─16,4 ± 2,5 vs. ─17,4 ± 3,8). Strain reduction reverted after treatment discontinuation (LA_GS% FU vs. T0 values: 20,4 ± 15,7 vs. 20,2 ± 11,1; LV_GS%: ─17,3 ± 3,3 vs. ─17,4 ± 3,8). Conclusions: Impairment of longitudinal deformation during mitoxantrone therapy may indicate a dysfunction related to early myocardial damage. These findings appear to be reversible after treatment discontinuation.

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